Abstract
Purpose: Variability of pathological tau in progressive supranuclear palsy (PSP) is reported, but no grading system has been established to account for it. Clinical syndromes associated with PSP-tau pathology now include PSP-Parkinsonism (PSP-P), in addition to classic Richardson’s syndrome (RS) and pure akinesia with gait freezing (PAGF). Regional variations in the types of tau lesions or differences in overall tau load may explain the clinical differences between these syndromes.
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