#202 : Adverse Effect on Pregnancy Outcome of Oocyte Preservation in Women with Advanced Maternal Age

Abstract

Background and Aims: For women facing inevitable fertility decline, oocyte freezing is an effective method for fertility preservation. However, few studies discussed the pregnancy potential from autologous freezing oocytes. Thus, this study characterizes the realistic outcomes of advanced maternal age patients who underwent oocyte thawing. Method: In this retrospective cohort study, the selected 694 patients underwent oocyte freezing cycles (n=1,163) and oocyte thawing cycles (n=218) from Mar 2020 to Mar 2022 at our fertility center. All oocytes thaw cycles from Mar 2020 to Mar 2022 at TFC clinic, including social egg freezing (SEF) and egg collection (EC). Parameters for IVF laboratory outcome and pregnancy outcome were recorded, and statistics were analyzed with Chi-square. Results: Those patients who underwent egg freezing at average age for 40.2 years old, and 49.7% were over 37 years old. Secondly, the survival rate of oocyte thawing was 94.9% in patients under 38 years old, 93.7% were 38-40 years old, and 91.4% for patients over 41 years old. For patients under 38 years old, 72.2% of were conceived for thawing cycle. For advanced maternal age groups, 46.7% for patients in 38-40 years old group, and only 23.3% of patients over 41 years old were conceived. The live birth rate declines as the age increases, which were 55.6%, 33.3%, and 7.1% in different age groups. Conclusion: In this study, we found the survival rate of oocytes and blastulation of embryo showed no significant difference between different age groups. Clinical pregnancy outcome demonstrated a dramatic decline in patients aged over 41 years old compared with other groups. Therefore, these data suggested that oocyte collection strategy is more suitable for patients who are under 41 years old.