201P - Prognostic Value of KI-67 Labeling Index in Patients with Ductal Intraepithelial Neoplasia of the Breast. Postsurgical Outcome for 1171 Women Cared for in One Single Institution Over 10 Years

Abstract

ABSTRACT The aim of this analysis was to investigate the prognostic relevance of Ki-67 labeling index (LI) in patients with Ductal Intraepithelial Neoplasia (DIN) of the breast. From January 1997 to December 2007, histopathologic and clinical data on 1,171 consecutive patients operated for DIN in a single institution were collected through the institutional clinical database. The study was performed in accordance with REMARK criteria. The independent prognostic role of Ki-67 LI was evaluated with a multivariable Cox regression model. Median age was 52 years, median Ki-67 LI 15% (range 1-80) and median follow-up was 86 months (range 1-192). A total of 872 (74.5%) patients underwent breast conservative surgery. Whole breast radiotherapy was administered to 356 patients, and 506 patients received endocrine treatment. Overall, 549 (46.9%) women were premenopausal at the time of diagnosis. In regard to histology, most DINs were solid or cribriform (75%), moderately-low differentiated (80%), with a low proliferating index (Ki-67 LI 20%), the 5-year cumulative incidence of breast recurrences were 9.4%, 10.3%, and 13.0% respectively [Hazard Ratio (HR)14-20 vs 20 vs Disclosure All authors have declared no conflicts of interest.