Abstract
2015: which new directions for Alzheimer's disease?
Highlights
Around 44 million people in the world are suffering from dementia including Alzheimer’s disease (AD)
The characteristics of AD consist in neurofibrillary tangles and senile plaques [dense extraneuronal deposits composed of amyloid β (Aβ)]
Abnormal or excessive tau phosphorylation by either kinases such as GSK3β, CDK5, DYRK1A for example or other known and unknown kinases are related to AD pathogenesis
Summary
Around 44 million people in the world are suffering from dementia including Alzheimer’s disease (AD). The other features linked to these two core pathological hallmarks of AD are inflammation, oxidative stress, progressive synaptic, and neuronal loss. Many AD molecular patterns have been screened to identify a potential therapeutic strategy. With the flood of evidence for tau pathology as key event of the disease development, the understanding of diverse tau functions and its molecular behavior is one of the major steps in the progression of our knowledge about the neurodegenerescence detected in AD.
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