Abstract
High-dose statins reduce serum low-density lipoprotein (LDL) cholesterol ≥ 50% and include atorvastatin 40 mg to 80 mg daily and rosuvastatin 20 mg to 40 mg daily [1]. Moderate-dose statins reduce serum LDL cholesterol 30% to 49% and include atorvastatin 10 mg to 20 mg daily, rosuvastatin 5 mg to 10 mg daily, simvastatin 20 mg to 40 mg daily, pravastatin 40 mg to 80 mg daily, lovastatin 40 mg daily, fluvastatin XL 80 mg daily, fluvastatin 40 mg twice daily, and pitavastatin 2mg to 4 mg daily [1]. Low-dose statins reduce serum LDL cholesterol less than 30% and include simvastatin 10 mg daily, pravastatin 10 mg to 20 mg daily, lovastatin 20 mg daily, fluvastatin 20 mg to 40 mg daily, and pitavastatin 1 mg daily [1].
Highlights
High-dose statins reduce serum low-density lipoprotein (LDL) cholesterol ≥ 50% and include atorvastatin 40 mg to 80 mg daily and rosuvastatin 20 mg to 40 mg daily [1]
If high-dose statins are associated with adverse effects in patients with atherosclerotic cardiovascular disease (ASCVD), moderate-dose statins are recommended if tolerated with a class I indication
The American College of Cardiology (ACC)/American Heart Association (AHA) guidelines state that persons with a serum LDL cholesterol ≥ 190 mg/dL or serum triglycerides ≥ 500 mg/dL should be investigated for secondary causes of hyperlipidemia
Summary
High-dose statins reduce serum low-density lipoprotein (LDL) cholesterol ≥ 50% and include atorvastatin 40 mg to 80 mg daily and rosuvastatin 20 mg to 40 mg daily [1]. These guidelines recommend use of high-dose statins in men and in women aged 75 years and younger with clinical evidence of ASCVD with a class I indication.
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