2003 REDEFINING CONTRAST MEDIA NEPHROPATHY BY EVALUATING RENAL FUNCTION DURING INTRAVENOUS UROGRAPHY (IVU) WITH NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL)

Abstract

You have accessJournal of UrologyImaging/Radiology: Uroradiology I1 Apr 20102003 REDEFINING CONTRAST MEDIA NEPHROPATHY BY EVALUATING RENAL FUNCTION DURING INTRAVENOUS UROGRAPHY (IVU) WITH NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) Achilleas Ploumidis, Efraim Serafetinides, Katerina Kalantoni, Ioannis Kaskarelis, Despoina Perrea, Prodromos Philippou, and Demetrios Delakas Achilleas PloumidisAchilleas Ploumidis More articles by this author , Efraim SerafetinidesEfraim Serafetinides More articles by this author , Katerina KalantoniKaterina Kalantoni More articles by this author , Ioannis KaskarelisIoannis Kaskarelis More articles by this author , Despoina PerreaDespoina Perrea More articles by this author , Prodromos PhilippouProdromos Philippou More articles by this author , and Demetrios DelakasDemetrios Delakas More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.2036AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Intravenous urography is still a popular study of the upper urinary tract. Cases of contrast-induced nephrotoxocity have been reported with an increase of serum creatinine in the days following the examination. The rapid expression of NGAL in serum and urine following renal tubular injury suggest a possible role as an early and reliable marker of renal function. We studied the expression of NGAL in blood and urine samples of patients undergoing IVU. METHODS Approval was obtained from the ethical committee of our institution. Forty consecutive patients with history of flank pain and/or hematuria who underwent IVU were evaluated. Age, sex, height, weight, BMI, presence of stones, distension of upper urinary tract and delay in renal excretion were documented. Patients with preexisting renal disease and urinary tract infection were excluded. Serial urine and blood samples were obtained: prior (T0) to contrast injection, 4h after (T1) and 24h after (T2) administration. HCT, Hgb, creatinine and urea, CRP were measured in the serum samples, while NGAL was assayed by sensitive ELISA in both serum and urine samples. One-way ANOVA and Independent sample t-test was used to compare means. Pearson's correlations between various parameters were evaluated. A p-value of less than 0.05 was considered statistically significant. RESULTS Serum NGAL (ng/mL) significantly increased (p < 0.05) from T0 (mean: 93.18) to T1 (mean: 116.21) and consequently decreased (P = 0.020) at T2 (mean: 92.12). Urine NGAL significantly increased (T0 mean: 31.58, T1 mean: 48.26, P <0.05) and decreased at initial levels (T2 mean: 33.13). No statistically significant correlations were observed among serum and urine NGAL at T0 and T1 with any of the continuous or categorical variables studied. CONCLUSIONS Administration of contrast media during IVU causes transient implications in renal function as documented by increase of serum and urine values of NGAL. It appears that NGAL is an early marker and sensitive marker of contrast-induced renal damage during IVU. Athens, Greece© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e777 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Achilleas Ploumidis More articles by this author Efraim Serafetinides More articles by this author Katerina Kalantoni More articles by this author Ioannis Kaskarelis More articles by this author Despoina Perrea More articles by this author Prodromos Philippou More articles by this author Demetrios Delakas More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...