Abstract
Study Objective This study aimed to compare the survival outcomes of NACT followed by laparoscopic or open radical hysterectomy versus CCRT in patients with locally advanced cervical cancer. Design Retrospective single-center study. Setting Retrospective single-center study. Patients or Participants Patients who were diagnosed as cervical cancer stage Ib1 to IVA at the Korea University Guro Hospital (February 2002∼ March 2014). Interventions NACT followed by laparoscopic or open radical hysterectomy versus CCRT. Measurements and Main Results Patients were categorized into two groups according to treatment method: NACT followed by laparoscopic and open radical hysterectomy with or without adjuvant chemotherapy (NCRH group) and concurrent chemoradiation (CCRT group). Survival outcomes and morbidity of the treatment were compared between the two groups using the Kaplan-Meier's analysis. Conclusion Neoadjuvant chemotherapy followed by laparoscopic and open radical hysterectomy seems to be a safe treatment option for locally advanced cervical cancer, in terms of similar survival outcomes and morbidity of treatment with CCRT. However, the present study is too limited to permit conclusions due to its small sample size and retrospective design despite statistical methods for adjusting confounding factors.
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