#200 : The Impact of Serum Progesterone(P4) Level on the Day of Embryo Transfer on Art Outcome

Abstract

Background and Aims: Physiologically serum progesterone level fluctuates among different stages of pregnancy. The serum level and tissue level of P4 are poorly correlated and also affected by the route of administration, thus creating a challenge for monitoring. Our goal was to determine whether P4 levels on the day of embryo transfer predict pregnancy outcomes in artificial FET cycles. Method: This was a prospective cohort study conducted from Feb 2022 to Dec 2022. Around 337 patients who underwent IVF/ICSI, irrespective of single or double frozen embryo transfer in an HRT cycle, were analyzed. Results: The participant’s mean age was 32.29±4.50 years with a BMI of 24.68±3.82 kg/m2, single embryo transfer vs double embryo transfer was 64(19.0%) vs 273(81.0%) and Serum P4 on day of ET was 28.66±12.51. Pearson’s correlation showed that serum P4 was negatively correlated with BMI (r: -0.131; P = 0.017). The serum P4 grouping was done as per the quartile distribution: Q1: <21.4 ng/ml; Q2: 21.4-27.1 ng/ml; Q3: 27.2-38.1 ng/ml; Q4: [Formula: see text]38.2 ng/ml. Clinical Pregnancy Rate (CPR), 60.7%(Q1); 68.4%(Q2); 64.5%(Q3); 73.8%(Q4); p=0.312) was not significantly different between a female with serum P4 within different quartiles. Miscarriage rates (2.0%, 1.9%, 3.3%, 1.6%; p=0.935) & Ongoing Pregnancy Rates were (48.3%, 56.6%, 44.3%, and 65.2%, respectively, in each quartile. Conclusion: The serum level of Progesterone on the day of embryo transfer while using intramuscular formulation in an artificial cycle had no significant impact on the clinical pregnancy rate.