200 Prevalence of dyslipidaemia in an Irish adult cystic fibrosis cohort

Abstract

Patients with cystic fibrosis (PWCF) are typically prescribed high calorie, high fat diets. With improved survival, there is emerging data that suggests an increased risk of cardiovascular disease. This study examines the prevalence of dyslipidaemia and its associated clinical phenotype in an Irish adult CF population. Biometric data and fasting lipid profiles were collected from patients attending annual assessment at the CF day unit between August 2012 and August 2013. Phenotypic information was collected from patient charts. 98 participants (mean age 28±10) were included in the study. Of this sample, 31% had CF-related diabetes and 83% were pancreatic insufficient. Across the population, mean and median lipid profiles were normal. However, 25% had lower HDL, 17% had elevated triglycerides, 17% elevated LDL, and 8% elevated total cholesterol. Total cholesterol and LDL were found to increase with increasing age and BMI. Increased total cholesterol was strongly correlated with increased LDL. On subgroup analysis, pancreatic sufficient subjects were more likely to have higher LDL (p< 0.001) and 63% of these had higher than optimal LDL. Diabetics were more likely to have higher triglycerides (p< 0.05) and 29% had higher than optimal levels. Men were found to have lower total cholesterol (p = 0.007) and lower HDL (p = 0.001). With increasing age, dyslipidaemia is an important emerging cardiovascular risk factor for PWCF. This is the first study to show this in a European population and is in keeping with previous studies.