Abstract
Commensal microbes and humans have coevolved toward a symbiotic relationship. In healthy individuals, the human microbiome has a vital role in the development of the innate and adaptive immune system, inducing protective and regulatory immunity, and the immune system maintains an optimal balance of microbes. Several acute and chronic skin conditions are a result of imbalances in the host-microbiome relationship and are accompanied by epidermal barrier disruption. This research aims to develop three-dimensional (3D) in vitro skin models integrating microbiology and immune cells to simulate this complex relationship and the effects on epidermal health.
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