200 Efficacy of Mite Sublingual Immunotherapy in 130 Children with Atopic Dermatitis

Abstract

BackgroundAtopic dermatitis (AD) is a chrinic inflammatory skin disease with increasing prevalence. The aim of this study was to investigate the efficacy and safety of mite sublingual immunotherapy (SLIT) in children with atopic dermatitis (AD).MethodsA total of 178 AD patients IgE-proved (class ≥3) Dermatophogoicles farinae sensitization. The treatment group (n = 130, 87 male and 43 female, age 2.5–14, SCORAD>7) were given sublingual drops of Dermatophogoicles farinae. They received increasing doses and concentration. Conventional treatment was added in the beginning. The 48 AD cases in the control group were treated with conventional drugs. The treatment time of SLIT is from 7 months to 2.5 years.ResultsIn the 130 patients of treatment group, 18 cases were considered cured, 39 got a marked effect, 58 were effective and 15 got no effect, for a total effective rate of 88.46% (115/130). In the control group, 8 got a marked effect, 20 were effective and 20 got no effect, the total effective rate was 58.33% (28/48). There is a statistically significant difference between the treatment group and the control group (p©,0.05). The patients' status of asthma and / or allergic rhinitis were improved after their received the sublingual immunotherapy with no emergence of new allergic diseases or significant side effects.ConclusionsSLIT appears to be an effective treatment of children with AD.