200 - Dietary fatty acid composition influences levels of fatty acid ethanolamides but not energetics in syrian golden hamsters

Abstract

The incidence of obstructive sleep apnea (OSA) in patients undergoing weight-loss surgery is underdiagnosed and is as high as 86% to 96%. No studies have definitively demonstrated in excessively obese patients with an average BMI of approximately 55, that the diagnosis and treatment of OSA leads to improved surgical outcomes. This prospective study is recruiting participants from a group of patients electing to undergo Roux-en-Y gastric bypass surgery at a Centre of Excellence in Toronto, Ontario. Patients not previously diagnosed with obstructive sleep apnea were subjected to both the Berlin & STOPbang questionnaires, preoperatively. All patients underwent overnight polysomnographic testing and the results of their sleep study were compared to the risk associated of having OSA based on the responses from the questionnaires. Preliminary results reveal that patients found to be at high risk for sleep apnea on the Berlin Questionnaire were seen in 36% of the patients with severe OSA, while 3% had moderate sleep apnea. Eighteen per cent of the patients with severe sleep apnea and 15% of the patients with moderate sleep apnea were low risk on the Berlin Questionnaire. Eighteen per cent of the patients who were considered to be high risk on the Berlin Questionnaire had no evidence of significant sleep apnea. Thirty-five per cent of the patients with STOP-Bang scores of two or greater had sleep studies which confirmed moderate to severe sleep apnea. Twenty-one per cent of patients with STOP-Bang scores of 1 or less were found to have moderate to severe sleep apnea. Thirteen per cent of patients with 1 or 0 on the STOP-Bang questionnaire had mild sleep apnea, while 7% of the patients with 2 or greater on the STOPBang questionnaire had no evidence of obstructive sleep apnea. These results suggest that the Berlin and STOP-bang questionnaires are limited in their ability to predict OSA in patients with average BMIs of 55 undergoing gastric bypass.