Abstract
In 492 college coeds, with acute, uncomplicated UTIs, documented by >105 colonies per ml. of the same bacteria in 2 or 3 consecutive urine cultures, E. coli and novobiocin resistant (SS) comprised 76.0% and 13.0% of the urinary pathogens, respectively, and other bacteria 11.0%. The in-vitro sensitivity testing revealed that SS were 100% sensitive to trimethoprim, trimethoprim/sulfamethoxozole, nitrofurantoin, and cephalexin; 91.0% to ampicillin; 93.0% to sulfasoxozole and 0.0% to nalidixic acid. Patients with either E. coli or SS organism presented with similar symptoms of an acute lower tract infection. Costovertebral angle tenderness was noted in 21.0% of the patients with SS and in 10.0% of those with E. coli. Fever >99.5C. was present in 15.0% of patients with SS and in 25.0% of those with E. coli. Clinical response to therapy was similar for both groups. Isolation of SS from the periurethral (52.0%), vaginal (31.0%), and rectal (11.5%) areas could only be accomplished in patients who had this organism as the primary urinary pathogen. SS was the second most common urinary pathogen isolated after E. coli in young women.
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