Abstract
Retinal arterio-venous shunts are present in ROP stage 3 +. Chorioidal changes are not detectable by ophthalmoscopy. To study hemodynamic changes occuring with ROP and cryotherapy (CTx), we made prospective Doppler studies of the mean BFV (area under the curve) in the superior ophthalmic vein (SOV) and the ophthalmic artery (OA) in 7 VVLBWI, GA 27 (25-29) wks, birthweight 760 (480-990)g (A). 9 infants with symmetric ROP 3+ (3 of group A), GA 27 (25-29) wks, were studied before (B) and after CTx (C). Controls without ROP: GA 29 (25-33) wks (D). Criteria for diagnosis of ROP and CTx were according to the CTx-ROP study (Pediatrics 81:697-706,1988). (* = p<0.05: A, C&D vs.B)The increase of SOV-BFV preceeded ophthalmoscopic retinal changes in group A (n=3) by 14(13-38)d. Conclusion: SOV-BFV is increased in ROP 3+ and normalizes with CTx. Since the SOV drains the chorioid, our data may indicate, that chorioidal hemodynamic changes preceed ophthalmoscopic retinal changes in ROP.
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