Abstract
The goal of this research is to generate cellular models of ASDs to elucidate its pathophysiology. Specifically, we study human-induced pluripotent stem cells (iPSCs) and subsequently derived neural progenitor cells (NPCs) and neural cells, which are stably knocked down for genes strongly associated with ASDs such as the chromatin modifier CHD8. Our goal is to compare these with cell lines that we have derived from patients with ASD with truncating CHD8 mutations.
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