結核菌とポリオウイルス2型の混合感染

Abstract

A 5-year-old female who fell ill with fever on 21st, Nov., 1980 showed vomiting and headache and then was diagnosed as aseptic meningitis. On 2nd Dec. she was admitted to this hospital. Thereafter she had intermittent fever and showed a positive Kernig's sign, stiffness of the neck, stupor, light paresis in left extremities and pain in the abdomen and other parts of body.Cerebrospinal fluid (C.S.F) showed pleocytosis and increment of protein contents. Bacteriological cultures of 3 C.S.F. were found positive for Mycobacterium tuberculosis and the complement fixing serum antibodies against poliovirus type 2 also appeared at the stage between the 27 and 48 days of disease and she showed the rise of the neutralizing antibody titer of serum against this virus strain in the course of the disease. Therefore, she was diagnosed as a complication of tuberculous meningitis and poliomyelitis due to poliovirus type 2.The origin of Mycobacterium tuberculosis was suspected her aunt who had had pulmonary tuberculosis. The origin of poliovirus type 2, however, could not be clarified because she had not received the live vaccine of poliovirus and nobody was suffered from poliomyelitis in her neighborhood. It was tried without effects to isolate the virus from her materials. Then, biological characters of the poliovirus type 2 with which she was infected could not be studied.