2. The prevention of induced peptic ulcer in dogs by feeding a hog stomach preparation

Abstract

1. A series of dogs in one group were fed “yellow” cinchophen; each dog developed peptic ulceration, which was indistinguishable from peptic ulcer in humans. 2. A series of control dogs in another group was also fed yellow cinchophen in exactly the same way, but in addition, the dogs were fed a mucosal and submucosal preparation from the hog’s stomach and duodenum. 3. The dogs in the group which were fed the hog stomach and duodenal preparation with cinchophen did not develop peptic ulcers as did the dogs in the group who were fed the cinchophen alone. 4. It is suggested from these preliminary experiments that some support is present for the previously reported belief of the author that a “protective principle” is elaborated by the human gastric mucosa and that this “protects” the stomach from self-digestion, and ulcer formation. 5. A “protective principle” may also be contained in the mucosa of the hog’s stomach and duodenum which was effective in preventing peptic ulcers in dogs whose controls had induced peptic ulcers indistinguishable from human peptic ulcers.