Abstract
Ace in the pack: 2-Nitrobenzyl esters of penams, which contain the characteristic core of penicillin-based antibiotics, are acylating inhibitors of penicillin-binding proteins R39 and BlaR-CTD. Docking experiments are in agreement with the experimental data and show that the 2-nitro group of the esters could play the role of a carboxylate group in interactions with the proteins.
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