Abstract
The term nicotinamide nucleotide transhydrogenase has been used in this chapter to denote those enzymes that catalyze the reversible transfer of hydrogen between the two naturally occurring nicotinamide nucleotides, NAD (H) and NADP (H). The term does not include those enzymes that catalyze transhydrogenation between only one naturally occurring nicotinamide nucleotide and an artificial nicotinamide nucleotide analog. Nicotinamide nucleotide transhydrogenases may be divided into two classes. One class is present in certain bacteria, and possibly in some plants, is an easily extractable, water-soluble enzyme. The other class is present in both certain bacteria and mitochondria, and is a firmly membrane-bound water-insoluble enzyme, functionally linked to the energy-transfer system of the bacterial or mitochondria1 membrane.
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