Abstract
Clinical neuroendocrinology provides some of the best methods for investigating the mechanism of action of psychotropic drugs in man. Most psychotropic drugs have potent effects upon the monoamines noradrenaline, dopamine and 5-hydroxytryptamine (5-HT), and some psychotropic drugs potentiate the actions of the inhibitory neurotransmitter ~/-aminobutyric acid (GABA). As each of these neurotransmitters has potent effects upon the neuroendocrine system in man, it follows that so will the psychotropic drugs. This review will look at the principal neuroendocrine effects of each of the major classes of psychotropic drugs. Note will be made of those neuroendocrine effects which are of clinical significance. The main focus of this review will be the contribution of clinical neuroendocrinology to contemporary understanding of the mechanism of action of psychotropic drugs.
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