Abstract
2-Methyl-4-amino-6-methoxy-s-triazine (CV 399) showed the marked central depressive actions in animal experiments, i. e. sedation in gross behavior, reduction of spontaneous motor activity and of hyperactivity induced by a variety of CNS excitants, potentation of pentobarbital or ethanol hypnosis, inhibition of hyperirritability of septal lesioned rats, analgesic effect, hypothermic effect and anticonvulsive action against electro- and chemoshocks. This agent blocked both of the conditioned avoidance response and the escape response in about the same extent in rats. This agent, however, did not exibit any effect on respiration and blood pressure level, and any change in brain serotonin content and in excretion of 5-hydroxyindole acetic acid in urine at the dose producing the above-mentioned effect.
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