Abstract
The title compound, C10H11NO5, is of interest with respect to its antidyslipidemic activity. It was prepared by reaction of 4-nitrophenol with ethyl 2-bromo-2-methylpropionate followed by ethyl ester hydrolysis. In the crystal, molecules are linked into centrosymmetric dimers by intermolecular O—H⋯O hydrogen bonds and the dimers are connected into chains by weak C—H⋯O interactions. The packing is further stabilized by offset π–π interactions between adjacent benzene rings with a centroid–centroid distance of 3.8643 (17) Å.
Highlights
The title compound, C10H11NO5, is of interest with respect to its antidyslipidemic activity. It was prepared by reaction of 4nitrophenol with ethyl 2-bromo-2-methylpropionate followed by ethyl ester hydrolysis
Molecules are linked into centrosymmetric dimers by intermolecular O—HÁ Á ÁO hydrogen bonds and the dimers are connected into chains by weak C—HÁ Á ÁO interactions
Symmetry codes: (i) −x+1/2, −y+3/2, −z+1; (ii) x, y+1, z
Summary
Gabriel Navarrete-Vazquez,a Hector Torres-Gomez,a Sergio Hidalgo-Figueroaa and Hugo Tlahuextb*. Key indicators: single-crystal X-ray study; T = 294 K; mean (C–C) = 0.004 A; R factor = 0.065; wR factor = 0.163; data-to-parameter ratio = 12.6. The title compound, C10H11NO5, is of interest with respect to its antidyslipidemic activity. It was prepared by reaction of 4nitrophenol with ethyl 2-bromo-2-methylpropionate followed by ethyl ester hydrolysis. Molecules are linked into centrosymmetric dimers by intermolecular O—HÁ Á ÁO hydrogen bonds and the dimers are connected into chains by weak C—HÁ Á ÁO interactions. Related literature For related literature on fibrate structures and hypolipidemic activity, see: Navarrete-Vazquez et al (2008); Henry et al (2003); Rath et al (2005); Djinovicet al. For details of the graph-set analysis of hydrogenbonding patterns, see: Bernstein et al (1995)
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