Abstract
2-Methoxy-1,4-Naphthoquinone (MNQ) Suppresses Protein Kinase C betaI, and #948;, and and #950; Expression in Raji Cells
Highlights
Cancer is a highly prevalent health burden with increasing incidents worldwide that still requires much attention for medical solutions
This study evaluates the capability of 2-Methoxy-1,4Naphthoquinone (MNQ) in regulating phorbol 12-myristate 13-acetate (PMA)-induced Protein Kinase C (PKC) expression in human Burkitt’s lymphoma cell line (Raji cells)
The suppressive effect of MNQ on PKC expression was compared to two standard of PKC inhibitors, rottlerin and staurosporine
Summary
Cancer is a highly prevalent health burden with increasing incidents worldwide that still requires much attention for medical solutions. The aberrant activation of these aforementioned kinases has been implicated in various cancers. MNQ isolated from Impatiens balsamina, Linn from the family of Balsaminaceae. This plant is an ornamental plant that has been widely used in Traditional Chinese Medicine to treat rheumatism, isthmus and crural aches, fractures, superficial infections, fingernail inflammation, various skin diseases treatment of difficult labor and puerperal pain, treatment of pains in the joint and skin affliction (Farnsworth and Cordell, 1976; Ding et al, 2008). This study was designed to investigate the suppressive effect of MNQ on the PKC activity and to identify the type of PKC isoform(s) expressed in Raji cells that could be regulated by MNQ
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