Abstract
Nanoparticles have been largely prepared from polymers, as they bear several advantages such as high reproducibility, control over physico-chemical properties, low cost, high stability, and wide availability of biodegradable polymers. Polymeric nanoparticles can be fabricated in two different ways, i.e. by polymerization of monomers or from preformed polymers. Various methodologies have been proposed for the preparation of nanoparticles depending upon the type of molecules to be delivered. Polymeric nanoparticles can be prepared by polymerization of monomers using various polymerization techniques such as emulsion, dispersion, and interfacial polymerization. Further, nanoparticles from polymers can be prepared by different approaches including solvent evaporation, salting-out, thermal denaturation, dialysis and supercritical fluid technology. This chapter outlines the different strategies for the preparation of polymeric nanoparticles employed for drug and gene delivery.
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