Abstract
Publisher Summary This chapter focuses on the human plasma factor XIII that is the subunit interactions and activation of zymogen. Blood coagulation factor XIII, or fibrin-stabilizing factor, is the plasma zymogen of the enzyme responsible for strengthening the clot network and for endowing it with a high resistance to lysis. The chapter also provides a description for separating the A 2 and B 2 subunits of the purified human plasma factor XIII by using the Ca 2+ -specific, thrombin- independent pathway for directly dissociating the zymogen. Breaking the heterologous association of subunits seems to be the key for activating factor XIII. However, purified human plasma factor XIII can become activated to express full transamidating enzyme activity even without the prior removal of the N-terminal activation peptide (AP) segments from the A subunits by thrombin.
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