Abstract
Glucose metabolism is a key metabolic pathway that orchestrates cellular homeostasis by generating ATP, nucleotides, and amino acids. Abnormal glucose signaling has been found in many diseases including cancers and inflammatory diseases. According to recent report, glycolysis contributes to pathogenesis of psoriasis and ablation of Glut1 attenuates animal models of psoriasis. While we were screening a molecular target for atopic dermatitis, we found the levels of glucose transporters including Glut1 (SLC2a1) and Glut3 (SLC2a3) are highly expressed in skin biopsies of dermatitis patients from multiple datasets. We demonstrated that administration of 2-deoxy-d-glucose (2DG) ameliorates animal models of 12-o-tetradecanoylphorbol-13-acetate (TPA) and oxazolone induced dermatitis using morphological and histological analysis. These results suggest that inhibition of glucose metabolism ameliorates dermatitis in animal models.
Highlights
As glucose is the most frequently used carbon source for mammals, biological functions of glucose and glucose metabolism have been extensively studied for many decades [1,2,3]
Th1 and Th17 types of immune responses are frequently activated in psoriasis, whereas Th2 type immune response is activated in atopic dermatitis [17,18,19]
Atopic dermatitis often occurs in infants and follows a chronic relapse with severe immune responses and psoriasis pathogenesis commonly occurs in the aged population [21]
Summary
As glucose is the most frequently used carbon source for mammals, biological functions of glucose and glucose metabolism have been extensively studied for many decades [1,2,3]. Recent studies expanded the role of glucose into immunology, stem cell, and cancer biology [4,5,6,7]. Atopic dermatitis and psoriasis have a different etiology along with distinct immune responses [17,18,19,20]. Atopic dermatitis often occurs in infants and follows a chronic relapse with severe immune responses and psoriasis pathogenesis commonly occurs in the aged population [21]. Expression levels of high Km glucose transporter Glut are upregulated in the lumen of sweat glands of atopic dermatitis patients [28]. These reports indicated that glucose metabolism may be associated with dermatitis. We determined whether glucose metabolism could be a target for dermatitis treatment
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