Abstract
Golgins are long (50-400 nm) rod-like membrane proteins, enveloping the Golgi apparatus (GA). They initially capture cognate cargo vesicle, to facilitate Snare-mediated membrane fusion. Most of them can phase separate and this may result to internal organization of the GA. Golgi matrix protein 130 (GM130), is the most abundant Golgin located at the cis Golgi. In our study of recombinant GM130 on supported bilayer system, we observed that GM130 self-assembles and phase separates into two distinct phases: A Mesh phase and a Condensate phase. Here we will describe the precise nature of these phases and their hypothetical physiological roles in the GA.
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