Abstract
We herein report 2 cases of acute tryptamine abuse. Both cases developed confusional state within 1 hour of 4- acetoxy-N-methyl-N-isopropyl-tryptamine ingestion. On admission, they presented confusion with marked mydriasis. In addition, one case showed hypertension, low grade fever, and hyperhidrosis, and the other showed the contraction of pilomotor muscles. Confusion and other autonomic symptoms improved gradually with intravenous drip infusion of saline. Tryptamine abuse should be considered as differential diagnosis in cases of acute confusional state with various autonomic symptoms.
Highlights
Designer tryptamine such as 5-methoxy-N, Ndiisopropyltryptamine (5-MeO-DIPT) and 5-methoxy-N-methylN-isopropyltryptamine (5-MeO-IPT) have been restricted legally in Japan
We report 2 cases of acute confusional state and multiple autonomic symptoms after oral ingestion of 4-acetoxy-N-methyl-N-isopropyltryptamine (4-AcO-MIPT)
A 27-year-old Japanese man was brought to the emergency room because he was excited after 30 minutes from ingestion of 10 mg of 4-AcO-MIPT (Figure 1)
Summary
Designer tryptamine such as 5-methoxy-N, Ndiisopropyltryptamine (5-MeO-DIPT) and 5-methoxy-N-methylN-isopropyltryptamine (5-MeO-IPT) have been restricted legally in Japan. These tryptamine analogs are popular among recreational drug users because of their hallucinogens. Previous reports described neuropsychiatric symptoms by these drugs are limited [1,2,3,4]. We report 2 cases of acute confusional state and multiple autonomic symptoms after oral ingestion of 4-acetoxy-N-methyl-N-isopropyltryptamine (4-AcO-MIPT)
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