Abstract
2-Butoxyethanol has been assessed as a Priority Substance under the Canadian Environmental Protection Act. Based primarily on investigations in experimental animals, the critical health effects associated with exposure to 2-butoxyethanol are alterations in hematological parameters associated with hemolysis and lesions of the forestomach in mice. A tolerable concentration of 11 mg/m3 has been derived, based upon the benchmark concentration for hematological effects in rats, quantitatively taking into account experimental data on interspecies variations in kinetics and dynamics. A tolerable concentration of 0.04 mg/m3 has also been derived based on the benchmark concentration for hyperplasia of the forestomach in mice. There is less confidence in this value, however, due to the paucity of information on mode of induction and, hence, relevance to humans.
Published Version
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