2-(Anilinomethyl)imidazolines as α 1 adrenergic receptor agonists: α 1a subtype selective 2′-heteroaryl compounds

Abstract

The structure–activity relationship of 2′-pyrrole, pyrazole and triazole substituted 2-(anilinomethyl)imidazolines as α 1 adrenergic agonists was investigated. The size and orientation of substituents, as well as the position of the heteroatoms, were found to have a profound effect on the potency and selectivity of the molecules. Potent α 1A subtype selective agonists have been identified.