“2-Amino glucose” as a substrate for synthesis of magnetically recoverable nanocatalyst NiFe2O4@SiO2@amino glucose for the green synthesis of novel bis (1,2-dihydro-4-hydroxy-2-oxoquinolin-3-yl)methanes

Abstract

2-Amino glucose ((2S,3R,4S,5S,6R)-2-amino-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol) as a substrate for the synthesis of NiFe2O4@SiO2@amino glucose supply an environmentally friendly procedure for the synthesis of bis(1,2-dihydro-4-hydroxy-2-oxoquinolin-3-yl)methanes through one-pot condensation of aldehyde or pyrazolo carbaldehyde and two equivalents of 4-hydroxyquinolin-2(1H)-ones in aqueous media. Eco‐friendliness, high purity of the desired products, short reaction time and easy workup procedure can be mentioned as the other advantages of this method. The structures of the synthesized 4-hydroxy-2(1H)-quinolone compounds were confirmed by 1H, 13C NMR and FTIR spectral data and elemental analyses.