2, 6-Di substituted pyrimidine based scaffolds: Synthesis, in- silico, and in-vitro Cell viability studies

Abstract

Existing of a cell depends on the pyrimidine moiety; it controls many functions which lead to alter the action of organs. Herein, we demonstrate the synthesis, biological evolution of newer pyrimidins. Titled compounds are formed with good yields, there In-silico studies indicating good drug likeness, drug score. The In- vitro cell viability studies using lipofectamine 2000 as reference, reveals that IC50 values for pyrimidine-II, III against GL261, pyrimidine- VIII,IX against 4 T1 Celline shows prominent results.