Abstract
The title compound, C21H24Br2N2O3, was synthesized by the condensation reaction of 3-methoxysalicylaldehyde with 4-(2-amino-3,5-dibromobenzylamino)cyclohexanol in a methanol solution. The dihedral angle between the two benzene rings is 76.4 (3)°. The cyclohexyl ring adopts a chair configuration. There is an intramolecular O—H⋯N hydrogen bond which affects the solid state conformation of the molecule. The crystal structure is stabilized by intermolecular O—H⋯O hydrogen bonds, forming chains running along the b axis.
Highlights
The title compound, C21H24Br2N2O3, was synthesized by the condensation reaction of 3-methoxysalicylaldehyde with 4-(2amino-3,5-dibromobenzylamino)cyclohexanol in a methanol solution
The crystal structure is stabilized by intermolecular O—HÁ Á ÁO hydrogen bonds, forming chains running along the b axis
R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger
Summary
The title compound, C21H24Br2N2O3, was synthesized by the condensation reaction of 3-methoxysalicylaldehyde with 4-(2amino-3,5-dibromobenzylamino)cyclohexanol in a methanol solution. The dihedral angle between the two benzene rings is 76.4 (3). The cyclohexyl ring adopts a chair configuration. There is an intramolecular O—HÁ Á ÁN hydrogen bond which affects the solid state conformation of the molecule. The crystal structure is stabilized by intermolecular O—HÁ Á ÁO hydrogen bonds, forming chains running along the b axis. Related literature For details of the pharmaceutical uses of the closely related compound ambroxol, systematic name 4-(2-amino-3,5-dibromobenzylamino)cyclohexanol, see: Felix et al (2008); Gaida et al (2005); Lee et al (2004). See: Allen et al (1987)
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