Abstract
Inflammation is implicated across a wide range of psychiatric disorders. Emerging data point to the role of inflammatory processes in neural reward circuitry disturbances, which are manifested clinically as anhedonia, the reduced capacity to experience pleasure. Adolescence is an ideal stage for examining this association, as it is a time when many disorders emerge and when reward function can be most disrupted. Further, anhedonia is prevalent among adolescents across disorders, exists on a continuum of severity, and predicts adult psychopathology. We present data from an ongoing research domain criteria (RDoC) study where we examine immunological markers in relation to anhedonia.
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