Abstract
The in vivo activity of the interferon (IFN) system was studied in 39 patients with chronic hepatitis B (CHB) and in 24 patients with chronic hepatitis type non-A, non-B (CHNANB). 2',5'-Oligoadenylate synthetase (2-5 A synthetase) activity was monitored in the liver and peripheral blood mononuclear cells (PBMCs). Liver 2-5 A synthetase activity was higher in HBeAg-positive CHB and CHNANB patients than in HBeAg-negative CHB patients or controls. The IFN system appeared to be preserved in CH patients. In HBeAg-positive CHB patients the changes in DNA-P activity indicated that PBMC 2-5 A synthetase activity depended on replication of hepatitis B virus(HBV). Exogenous IFN administration in patients with HBeAg-positive CHB significantly elevated 2-5 A synthetase activity in PBMCs, as well as in the liver. In measurement of 2-5 A synthetase activity of CHB patients, the IFN system seems to be important in regulating HBV replication and in the exacerbation of liver inflammatory activity.
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