2,5-Anhydro sugar diacid and 2,5-anhydro sugar diamine based C2 symmetric peptidomimetics as potential HIV-1 protease inhibitors

Abstract

Conformationally constrained molecular frameworks of the 2,5-anhydro sugar diacid ( 9) and 2,5-anhydro sugar diamines ( 10, 11) were used to construct architecturally beautiful novel C 2 symmetric peptidomimetics 1– 8. Although none of these compounds showed any significant HIV-1 protease inhibitory activity, further refinements in design may lead to protease inhibitors based on these rigid carbohydrate-derived scaffolds.