Abstract
Based on an easy and scalable method for the synthesis of quinoline derivatives substituted by fluorinated groups at both the C‐2 and C‐4 positions developed in our laboratory, we have devised an approach to the synthesis of a new series of unprecedented 2,4‐bis(fluoroalkyl)quinoline‐3‐carboxylates in just two steps. After standard saponification, the latter gave the corresponding 2,4‐bis(fluoroalkyl)quinoline‐3‐carboxylic acids, which served as pivotal intermediates for post‐functionalization reactions. Indeed, the carboxylic group could then be derivatized according to known procedures to introduce chemical diversity at the C‐3 position of these unprecedented structures. The resulting highly functionalized quinolines can serve as a platform for the development of biologically active molecules with strong potential for agrochemical research.
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