Abstract
Kinetics of 2,3-butanediol production by Klebsiella pneumoniae from glucose was studied in a cell recycle system with total recycle of biomass. Under these conditions productivity greater than batch or continuous system were obtained. However, when the cell concentration in the bioreactor built up to 40 g l −1, the production of 2,3-butanediol started decreasing. The coefficient of mass transfer for oxygen decreased significantly and the viscosity increased rapidly after this cell concentration was reached. The increase in viscosity was partially due to production of polysaccharides. This appears at high cell concentration, due to severe oxygen limitation, when the organism may switch from 2,3-butanediol to polysaccharide production.
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