Abstract
The title molecule, C25H17ClFN3S, contains indenothiazolyl (A), pyrazolyl (B), fluorophenyl (C) and chlorophenyl (D) groups. The dihedral angles between the ring planes A/B, B/C and B/D are 14.2 (1), 83.0 (1) and 6.5 (2)°, respectively. In the crystal, pairs of molecules related by inversion symmetry are linked by pairwise weak C—H...N interactions, forming dimers. These dimers interact through π–π contacts between the thiazolyl units [centroid-to-centroid distance = 3.826 (1) Å], forming chains along [010].
Highlights
Indeno[1,2-d]thiazoles act as histone deacetylase inhibitors (Zhou et al, 2013; Chordia et al, 2005)
As part of our studies in these areas we report the synthesis and structure of the title compound
The asymmetric unit consists of one molecule of the title compound
Summary
Indeno[1,2-d]thiazoles act as histone deacetylase inhibitors (Zhou et al, 2013; Chordia et al, 2005). Thiazoles and pyrazoles have various biological activities (Chhabria et al, 2016; Faria et al, 2017). As part of our studies in these areas we report the synthesis and structure of the title compound. The asymmetric unit consists of one molecule of the title compound. The twist angles between the planes through neighbouring ring pairs A/B, B/C and B/D are 14.2 (1), 83.0 (1) and 6.5 (2), respectively. Pairs of molecules related by inversion symmetry are linked by C—HÁ Á ÁN interactions, forming dimers in the crystal structure (Table 1, Fig. 2). Neighbouring dimers interact through – contacts involving the thiazolyl fragments with centroid-tocentroid distances of 3.826 (1) A , forming chains along [010]
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