2,3,4,5,6,7-Hexahydro-9,10-dimethoxy-1,2-benzothiazonin-3-one 1,1-dioxide

Abstract

The amide group in the nine-membered ring of the title compound, C13H17NO5S, has the trans conformation. The molecules are linked into infinite one-dimensional chains by bifurcated intermolecular N-H...O hydrogen bonds involving the amide O atom and one of the sulfonyl O atoms of the same neigh- bouring molecule. The compound was prepared by the Friedel-Crafts acylation of 1,2-dimethoxybenzene and glutaric acid anhydride, followed by reduction of the aryl ketone, esterification, chlorosulfonation, treatment with ammonia, saponification and cyclization of the corresponding 5-(2-sulfamoylphenyl)butanoic acid.