Abstract
Three new 2-(2-phenylethyl)chromone derivatives (1–3) and a new 2-(2-phenylethenyl)chromone derivative (4), together with two known 2-(2-phenylethyl)chromone derivatives (5–6), were isolated from agarwood originating from Gyrinops salicifolia Ridl. The structures of compounds 1–4 were elucidated by comprehensive spectroscopic techniques (UV, IR, 1D and 2D-NMR) and MS analysis, as well as by comparison with the literature. Compounds 1, 2, and 5 showed moderate cytotoxicity against human tumor K562, BEL-7402, and SGC-7901 cell lines with IC50 values of 5.76 to 20.1 µM.
Highlights
Agarwood (Chen-Xiang in Chinese) is the resinous heartwood of the plants from the Aquilaria or Gyrinops genus that belong to the family of Thymelaeaceae [1]
HSQC spectra showed that compound 1 contained a chromone nucleus by the signals at δC 107.6 aromatic ring (C-10, C-20 /60, C-30 /50, C-40) and two methylene (C-5), 144.3 (C-6), 152.0 (C-7), 102.8 (C-8), 115.8 (C-10) and 151.0 (C-9), as well as an α,β-unsaturated carbons at δC 32.1 (C-70 ) and 34.7 (C-80 )
Data between 3 and 5,8-dihydroxy-2-[2-(4-methoxyphenyl)ethyl]chromone [18] suggested that their structures were closely related, except that an additional hydroxy group was located at C-30 in
Summary
Agarwood (Chen-Xiang in Chinese) is the resinous heartwood of the plants from the Aquilaria or Gyrinops genus that belong to the family of Thymelaeaceae [1]. It is well known as a traditional medicinal and natural perfume material, and has become more and more prevalent in international trade [2,3]. As far as we know, the only report on chemical constituents of Gyrinops species is on the leaves and stems of Gyrinops walla [12]. It has been reported that 2-(2-phenylethyl)chromone derivatives and sesquiterpenes were the main chemical constituents of agarwood [5,6,14,15]. Activity against human tumor K562, BEL-7402, SGC-7901 cell lines is described
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