2.2]Benzoindenophane-Based Chiral Indenyl Ligands: Design, Synthesis, and Applications in Asymmetric C-H Activation.

Abstract

Development of chiral indenyl ligands for asymmetric C-H activation is a longstanding challenge, and extremely few successes have been achieved. In this paper, we describe a class of readily accessible, facilely tunable and user-friendly chiral indenyl ligands featuring a [2.2]benzoindenophane skeleton via a divergent synthesis strategy. The corresponding chiral indenyl rhodium catalysts were successfully applied in the asymmetric C-H activation reaction of O-Boc hydroxybenzamide with alkenes to give various chiral dihydroisoquinolone products (up to 97% yield, up to 98% ee). Moreover, the asymmetric C-H activation reaction of carboxylic acids with alkynes was also successfully accomplished, providing a range of axially chiral isocoumarins (up to 99% yield, up to 94% ee). Notably, this represents the first example of enantioselective transition metal catalyzed C(sp2)-H activation/oxidative coupling of benzoic acids with internal alkynes to construct isocoumarins. Given many attractive features of this class of indenyl ligands, such as convenient synthesis, high tunability and exclusive face-selectivity of coordination, its applications in more catalytic asymmetric C-H activation and in other asymmetric catalysis are foreseen.