1p36 deletion is associated with TNFRSF14 mutations in primary cutaneous follicle center lymphoma

Abstract

Background: Primary cutaneous follicle center lymphoma (PCFCL) is an indolent variant of follicular lymphoma (FL) with limited information available on the genetic background of the disease. The genetic hallmark of nodal FL, the t(14;18) translocation, affecting the BCL2 gene, is rare in PCFCL. Loss of 1p36, the most common secondary chromosomal abnormality in nodal FL, has been recently reported in 16.7% of PCFCL cases. The mutation analysis of TNFRSF14, the candidate gene in the 1p36 region has not yet been performed.