1P Sitravatinib + tislelizumab in patients with anti-PD-(L)1 refractory/resistant metastatic non-small cell lung cancer (NSCLC)

Abstract

Patients with metastatic NSCLC who are refractory/resistant (R/R) to anti-PD-(L)1 therapies have limited treatment options. Sitravatinib is a spectrum-selective tyrosine kinase inhibitor targeting TAM and VEGFR2 receptors, which can reduce the number of myeloid-derived suppressor cells, regulatory T cells, and increase the ratio of M1/M2 polarized macrophages, potentially augmenting antitumor immune responses. Tislelizumab, is an anti-PD-1 antibody engineered to minimize binding to FcγR on macrophages to abrogate antibody-dependent phagocytosis, a potential mechanism of resistance.