Abstract
IntroductionLiver cirrhosis is a major chronic disease that is associated with high morbidity and mortality.1 The associated co-morbidities and medical complications together with the use of complex and multiple drug...
Highlights
Liver cirrhosis is a major chronic disease that is associated with high morbidity and mortality.[1]
The associated co-morbidities and medical complications together with the use of complex and multiple drug therapies by patients with liver cirrhosis put them at an increased risk of developing medicine related problems (MRPs)
This review aims to systematically investigate the prevalence, causes and risk factors of MRPs in cirrhotic patients and to explore factors influencing the medicine use from patients and health care providers’ perspectives
Summary
Liver cirrhosis is a major chronic disease that is associated with high morbidity and mortality.[1]. Subjects and methods Eight online databases (PubMed, Scopus, CINAHL, The British library, PsycINFO, Web of Science, EMBASE, and Google scholar) were searched up to 30th Sep, 2018 with no start date Both quantitative studies including randomised controlled trials (RCTs), clinical trials and observational studies as well as qualitative studies were included in the review. Analgesics and sedatives were suspected to be among the most common drug classes associated with MRPs. The thematic synthesis of qualitative data identified three key themes: patient related factors including lack of patients’ knowledge about liver cirrhosis and its risk factors; health care related factors including lack of communication between healthcare professionals and patients; stigma and negativity including negative attitudes (misconceptions and discriminations) and negative consequences of liver cirrhosis. Future research should focus on assessing the impact of patientspecific education on medicine use by patients with liver cirrhosis
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