Abstract
Protein-nucleic acid interaction plays an essential role in the regulation of gene expression. Structural and binding information provides insight into the mechanism of protein-nucleic acid recognition. Although there are structural databases for protein-nucleic acid complexes, there exists no database for protein-nucleic acid binding. Thus, we have decided to develop the Thermodynamic Database for Protein-Nucleic Acid Interactions. It contains several important thermodynamic parameters, experimental conditions, structural information about proteins, nucleic acids and of the complex, and literature information. This database will be helpful for understanding the mechanism of proteinnucleic acid recognition. A WWW interface will help users to search the data based on various conditions with different sorting options for outputs.
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