1H NMR studies of homo and mixed ligand complexes of Tl + ion with several polyazamacrocycles

Abstract

Proton NMR was used as a probe to study the interaction of the Tl + ion with 9–18-membered macromonocyclic tri-, tetra-, and hexaamines in dimethylformamide (DMF) solution. A study of proton chemical shift of ligands as a function of Tl + ion to ligand mole ratio revealed that the complexation reactions occur in a stepwise manner. Formation of a 1:1 complex is followed by the addition of a second complexant molecule to form a homo-sandwich complex for triazamacrocycle ligands and a mixed ligand complex in the case of hexamethylhexacyclen (HMHCY) and 1,4,7-triazacyclononane ([9]aneN 3). The formation constants of resulting 1:1 and 1:2 (homo and mixed ligand sandwich) complexes in DMF solution were evaluated from computer fitting of the chemical shift-mole ratio data. The mixed ligand complexes may be more stable than the parent complex in which both ligands are the same. The influence of cavity size and substitution of methyl groups on nitrogen atoms of the macrocyclic ring the stability of the resulting complexes is discussed. The geometries of the tri- and tetraazamacrocycle ligands and their Tl + ion complexes were optimized by an ab initio method, and the calculated binding energies of resulting complexes were compared. Both the experimental and theoretical studies revealed that, in the presence of methyl groups, the stability of triazamacrocycle complexes with Tl + ion was decreased.