Abstract
The present study was to determine the effect of aged garlic extract (AGE) on alleviating diabetic cardiomyopathy (DCM)in rats. An experimental diabetic rat model was induced by a single dose (60mg/kg body weight) of I.P injection ofstreptozoticin (STZ). AGE was orally administrated at a dose of 500 mg/kg body weight. Metabolic profiles include serumglucose, insulin, total cholesterol and triacylglycerols and myocardial enzymes activities as creatine kinase-isoenzyme(CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) were determined. The obtained resultsindicated that administration of AGE increased the body weight and insulin concentration, meanwhile, significantdecrease in serum glucose concentration, CK-MB and LDH activities when compared with untreated induced diabeticgroup. Total cholesterol, triacylglycerols and AST showed non-significant changes in serum values in AGE treateddiabetic rats in comparing with STZ-induced diabetic group. From the obtained results it could be concluded that, AGEhas great potential therapeutic effect in the diabetic cardiomyopathy and other complications of coronary heart disease
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