Abstract
The present study was to determine the effect of aged garlic extract (AGE) on alleviating diabetic cardiomyopathy (DCM)in rats. An experimental diabetic rat model was induced by a single dose (60mg/kg body weight) of I.P injection ofstreptozoticin (STZ). AGE was orally administrated at a dose of 500 mg/kg body weight. Metabolic profiles include serumglucose, insulin, total cholesterol and triacylglycerols and myocardial enzymes activities as creatine kinase-isoenzyme(CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) were determined. The obtained resultsindicated that administration of AGE increased the body weight and insulin concentration, meanwhile, significantdecrease in serum glucose concentration, CK-MB and LDH activities when compared with untreated induced diabeticgroup. Total cholesterol, triacylglycerols and AST showed non-significant changes in serum values in AGE treateddiabetic rats in comparing with STZ-induced diabetic group. From the obtained results it could be concluded that, AGEhas great potential therapeutic effect in the diabetic cardiomyopathy and other complications of coronary heart disease
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have