1B.06

Abstract

Objective: The masked hypertension (MH) is the actual problem of medicine due to association with high risk of cardiovascular complications. The aim of study was assess MH prevalence and markers in organized cohort (employees with antihypertensive treatment [masked noneffective therapy; MNT] or without it [MH]). Design and method: Cross-sectional cohort study of employees (n = 477) of large industrial enterprise with office blood pressure (OBP)<140/90 mm Hg. The ambulatory BP monitoring (ABPM), ECG, echocardiography, anthropometry, blood chemistry were performed. The selection criterion for ABPM records was the quality adequate for sophisticated analyses: duration> = 24 hours, absence of data gaps>1 hour. The criterion for MH and MNT were OBP<140/90 mm Hg and mean BP in working hours (08:00–17:00, [WBP])>134 and/or 84 mm Hg. We defined MH and MNT markers as patient characteristics significantly associated with the ratio of OBP and WBP. Results: The total number of employees with normal OBP was 185, mean age 53.2 ± 5.5, males – 38.4%. The MH prevalence was 10.8%, MNT – 34.6% (45.4% of employees with normal OBP). The main differences included: between MH group and normotensive persons – higher left ventricular (LV) mass index (129.0 ± 21.2 vs. 109.5 ± 28.8 g/m2 in males, 105.2 ± 43.2 vs. 82.4 ± 25.3 g/m2 in females, p < 0.05) and weight (85.4 ± 13.3 vs. 81.3 ± 10.1 kg, p = 0.05); between MNT group and employees with effective antihypertensive treatment (normal OBP and WBP) – weight (89.4 ± 16.1 vs. 85.4 ± 15.8 kg, p < 0.05), triglycerides (1.56 ± 0.95 vs. 1.23 ± 0.55 mmol/l, p < 0.01) and uric acid (388.5 ± 89.5 vs. 357.2 ± 84.5 mmol/l, p < 0.05), LV hypertrophy signs (the interventricular septum thickness 1.34 ± 0.19 vs. 1.26 ± 0.19 mm, the LV posterior wall thickness 1.27 ± 0.13 vs. 1.21 ± 0.16, p < 0.05), incidence of coronary heart disease (n = 3 vs. n = 15, p < 0.05) and the higher number of patients with angiotensin converting enzyme inhibitors intake (64.1% vs. 46.9%, p < 0.05). In this study the professional factors were not associated with MH and MNT. Conclusions: MH and MNT in organized cohort were diagnosed in approximately 50% employees. The MH and MNT markers of this group include traditional risk factors. High MH and MNT prevalence makes it necessary to detect these hypertension phenotypes carefully.