Abstract
The present study was carried out to determine the relationship of β1- and β2-subtype to amylase release and cyclic AMP (cAMP) accumulation in rat parotid tissue. In in vitro experiments, β-adrenergic agents (isoproterenol and dobutamine)-induced amylase release and cAMP accumulation were all completely inhibited by the β1-antagonist metoprolol, but incompletely inhibited by the β2-antagonist butoxamine. The β2-agonist procaterol caused little or no amylase release or cAMP accumulation. Our results suggest that both amylase release and cAMP accumulation in rat parotid tissue may be selectively induced by adrenergic stimulation.
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